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Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality.

De Luca V, Voineskos D, Wong GW, Shinkai T, Rothe C, Strauss J, Kennedy JL

Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, R-30, Toronto, Ontario, Canada M5T 1R8. Vincenzo_Deluca@camh.net

Allele and haplotype frequencies of a promoter polymorphism in the gene encoding tryptophan hydroxylase (TPH2) did not differ in 83 suicidal schizophrenic patients compared with 170 non-suicidal schizophrenic patients. These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia.

Published 20 April 2005 in Psychiatry Res, 134(2): 195-8.
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